Yuko was Akira's younger sister raised with him, Kazuma Kiryu and Yumi Sawamura in Shintaro Kazama's Sunflower Orphanage. She suffered from a disease which had her periodically going to the hospital since 1984. In 1996, her final possible surgery and reliance on her elder brother is the reason Kazuma Kiryu takes the fall for Sohei Dojima's murder. She died shortly after and her death spiraled Nishikiyama's descent into darkness.

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